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Cu2+-labeled, SPION loaded porous silica nanoparticles for cell labeling and multifunctional imaging probes

Paper ID Volume ID Publish Year Pages File Format Full-Text
8574 598 2010 8 PDF Available
Title
Cu2+-labeled, SPION loaded porous silica nanoparticles for cell labeling and multifunctional imaging probes
Abstract

We have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell tracking with magnetic resonance (MR) imaging and positron emission tomography (PET). Herein we report the synthesis, surface functionalization and characterization of the magnetic nanoparticle-based probes and evaluate their cell-labeling efficacy, cytoxicity and relaxivity in comparison to one of the most commonly utilized MRI contrast agents, Feridex®.

Keywords
Cell viability; Copper; Cytotoxicity; In vitro test; MRI (magnetic resonance imaging); Surface modification
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Cu2+-labeled, SPION loaded porous silica nanoparticles for cell labeling and multifunctional imaging probes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 10, April 2010, Pages 2866–2873
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us