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A study of a biodegradable Mg–3Sc–3Y alloy and the effect of self-passivation on the in vitro degradation ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
858 67 2013 10 PDF Available
Title
A study of a biodegradable Mg–3Sc–3Y alloy and the effect of self-passivation on the in vitro degradation ☆
Abstract

Magnesium and its alloys have been investigated for their potential application as biodegradable implant materials. Although properties of magnesium such as biocompatibility and susceptibility to dissolution are desirable for biodegradable implant applications, its high degradation rate and low strength pose a significant challenge. A potential way to reduce the initial degradation rate is to form a self-passivating protective layer on the surface of the alloy. Oxides with a low enthalpy of formation result in a strong thermodynamic driving force to produce oxide surfaces that are more stable than the native oxide (MgO), and possibly reduce the initial degradation rate in these alloys. In the present study a ternary Mg–3 wt.% Sc–3 wt.% Y alloy was investigated and its oxidation behavior studied. The effect of surface passivation on the in vitro degradation rate was studied and the degradation products identified. The results show that the oxide provided an initial degradation barrier and 24 h oxidation resulted in a negligible degradation rate for up to 23 days. Furthermore, the degradation products of the alloy showed no significant toxicity to osteoblastic cells, and cell proliferation studies confirmed cell attachment and proliferation on the surface of the oxidized alloy.

Keywords
Surface passivation; Magnesium; Oxidation; Yttrium; Scandium
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A study of a biodegradable Mg–3Sc–3Y alloy and the effect of self-passivation on the in vitro degradation ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 2, February 2013, Pages 5331–5340
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us