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Preservation, sterilization and de-epithelialization of human amniotic membrane for use in ocular surface reconstruction

Paper ID Volume ID Publish Year Pages File Format Full-Text
8622 600 2010 10 PDF Available
Title
Preservation, sterilization and de-epithelialization of human amniotic membrane for use in ocular surface reconstruction
Abstract

In the past 20 years, human amniotic membrane (AM) has become widely used as an ophthalmic surgical patch as well as a substrate for stem cell tissue equivalents for ocular surface reconstruction. AM reduces ocular surface scarring and inflammation, and enhances epithelialization. In addition, it shows limited immunogenicity and some anti-microbial properties. Before being applied clinically, the donor of AM is required to undergo a thorough health screening and the membrane has to undergo an accepted processing routine, which includes preservation, sterilization and de-epithelialization. There have been various articles describing methods in preserving, sterilizing and de-epithelializing AM. Each preparation technique has been reported to have differential effects on the physical and biological properties of the AM. Therefore, it is difficult to establish a standardized procedure. In this review, we discuss the present techniques and several novel, new approaches in the preparation of AM for use in ocular surface reconstruction, and their impact on AM structure and biological activity.

Keywords
Membrane; Wound healing; Extracellular matrix; Growth factors; Ophthalmology; Biocompatibility
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Preservation, sterilization and de-epithelialization of human amniotic membrane for use in ocular surface reconstruction
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 2, January 2010, Pages 216–225
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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