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Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol)

Paper ID Volume ID Publish Year Pages File Format Full-Text
8642 601 2009 10 PDF Available
Title
Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol)
Abstract

A series of amphiphilic alternative block polyurethane copolymers based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P3/4HB) and poly(ethylene glycol) (PEG) were synthesized by a coupling reaction between P3/4HB-diol and PEG-diisocyanate, with different 3HB, 4HB, PEG compositions and segment lengths. Stannous octanoate was used as catalyst. The chemical structure, alternative block arrangement, molecular weight and distribution were systematically characterized by FTIR, 1H NMR, GPC and composition analysis. The thermal property was studied by DSC and TGA. Platelet adhesion study revealed that the alternative block polyurethanes possess excellent hemocompatibility. CCK-8 assay illuminated that the non-toxic block polyurethanes maintain rat aortic smooth muscle cells (RaSMCs) good viability. The in-vitro degradation of the copolymers in PBS buffer solution and in lipase buffer medium was investigated. Results showed that the copolymer films exhibit different degradation patterns in different media from surface erosion to diffusion bulk collapsing. The synthetic methodology for the alternative block polyurethanes provides a way to control the exact structure of the biomaterials and tailor the properties to subtle requirements.

Keywords
Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P3/4HB); Poly(ethylene glycol) (PEG); Alternative block polyurethane; Hemocompatibility; Cell viability; Degradation
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Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 16, June 2009, Pages 2975–2984
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us