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Deep magnetic capture of magnetically loaded cells for spatially targeted therapeutics

Paper ID Volume ID Publish Year Pages File Format Full-Text
8667 602 2010 11 PDF Available
Title
Deep magnetic capture of magnetically loaded cells for spatially targeted therapeutics
Abstract

Magnetic targeting has recently demonstrated potential in promoting magnetically loaded cell delivery to target lesion, but its application is limited by magnetic attenuation. For deep magnetic capture of cells for spatial targeting therapeutics, we designed a magnetic pole, in which the magnetic field density can be focused at a distance from the pole. As flowing through a tube served as a model of blood vessels, the magnetically loaded mesenchymal stem cells (MagMSCs) were highly enriched at the site distance from the magnetic pole. The cell capture efficiency was positively influenced by the magnetic flux density, and inversely influenced by the flow velocity, and well-fitted with the deductive value by theoretical considerations. It appeared to us that the spatially-focused property of the magnetic apparatus promises a new deep targeting strategy to promote homing and engraftment for cellular therapy.

Keywords
Magnetism; In vitro test; Mesenchcymal stem cell; NanoparticleMagMSCs, Magnetically loaded mesenchymal stem cells; SPIO, Superparamagnetic oxide nanoparticles; MSCs, Mesenchymal stem cells; PLL, Poly-l-lysine; TEM, Transmission electron microscopy; B, Mag
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 8, March 2010, Pages 2130–2140
Authors
, , , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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