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Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules

Paper ID Volume ID Publish Year Pages File Format Full-Text
8772 605 2009 7 PDF Available
Title
Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules
Abstract

Cell encapsulation has been broadly investigated as a technology to provide immunoprotection for transplanted endocrine cells. Here we develop a new fabrication method that allows for rapid, homogenous microencapsulation of insulin-secreting cells with varying microscale geometries and asymmetrically modified surfaces. Micromolding systems were developed using polypropylene mesh, and the material/surface properties associated with efficient encapsulation were identified. Cells encapsulated using these methods maintain desirable viability and preserve their ability to proliferate and secrete insulin in a glucose-responsive manner. This new cell encapsulation approach enables a practical route to an inexpensive and convenient process for the generation of cell-laden microcapsules without requiring any specialized equipment or microfabrication process.

Keywords
Cell encapsulation; Hydrogel microcapsules; Alginate; Diabetes; Polypropylene mesh; Microfabrication
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Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 36, December 2009, Pages 6896–6902
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us