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Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
8778 605 2009 8 PDF Available
Title
Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging
Abstract

Nanoemulsions are increasingly investigated for the delivery of hydrophobic drugs to improve their bioavailability or make their administration possible. In the current study, oil-in-water emulsions with three different mean diameters (30, 60, and 95 nm) were developed as a new multimodality nanoparticle platform for tumor targeting and imaging. To that aim, hydrophobically coated iron oxide particles were included in the soybean oil core of the nanoemulsions to enable their detection with magnetic resonance imaging (MRI), while the conjugation of a near infrared fluorophore allowed optical imaging. The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl's staining of histological tumor sections ex vivo.

Keywords
Oil-in-water emulsions; Iron oxide nanocrystals; Tumor targeting; Multimodal imaging; Nanoparticle
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Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 36, December 2009, Pages 6947–6954
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us