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A poly(d,l-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography

Paper ID Volume ID Publish Year Pages File Format Full-Text
8785 606 2009 9 PDF Available
Title
A poly(d,l-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography
Abstract

Porous polylactide constructs were prepared by stereolithography, for the first time without the use of reactive diluents. Star-shaped poly(d,l-lactide) oligomers with 2, 3 and 6 arms were synthesised, end-functionalised with methacryloyl chloride and photo-crosslinked in the presence of ethyl lactate as a non-reactive diluent. The molecular weights of the arms of the macromers were 0.2, 0.6, 1.1 and 5 kg/mol, allowing variation of the crosslink density of the resulting networks. Networks prepared from macromers of which the molecular weight per arm was 0.6 kg/mol or higher had good mechanical properties, similar to linear high-molecular weight poly(d,l-lactide). A resin based on a 2-armed poly(d,l-lactide) macromer with a molecular weight of 0.6 kg/mol per arm (75 wt%), ethyl lactate (19 wt%), photo-initiator (6 wt%), inhibitor and dye was prepared. Using this resin, films and computer-designed porous constructs were accurately fabricated by stereolithography. Pre-osteoblasts showed good adherence to these photo-crosslinked networks. The proliferation rate on these materials was comparable to that on high-molecular weight poly(d,l-lactide) and tissue culture polystyrene.

Keywords
Polylactide; Photo-crosslinking; Non-reactive diluent; Rapid prototyping; Stereolithography; Tissue engineering scaffolds
First Page Preview
A poly(d,l-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issues 23–24, August 2009, Pages 3801–3809
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering