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In vivo evaluation of vaginal films for mucosal delivery of nitric oxide

Paper ID Volume ID Publish Year Pages File Format Full-Text
8803 606 2009 8 PDF Available
Title
In vivo evaluation of vaginal films for mucosal delivery of nitric oxide
Abstract

Nitric oxide (NO)-releasing vaginal films were developed and evaluated as a potential advanced treatment option for female sexual arousal disorder (FSAD). The polymeric films containing s-nitrosoglutathione (GSNO), an endogenous NO donor, were prepared using the reduced-pressure drying method. The surface morphology, thermal/mechanical properties, stability, loading efficiency and physicodynamic properties were characterized and the pharmacological activities were evaluated through in vitro and in vivo studies. The GSNO films were homogeneous and transparent, and showed suitable mucoadhesiveness and mechanical properties. The release profiles of NO from the GSNO films followed the first-order kinetic pattern and NO activated the NO–cGMP signaling pathway in vaginal cells. The GSNO films significantly enhanced the duration of action of GSNO and vagina blood perfusion in the rat model without causing any cytotoxic effects. The NO-releasing vaginal films might be used as a promising treatment device against FSAD.

Keywords
Nitric oxide; NO-releasing vaginal film; Female sexual arousal disorder; Vagina blood flow
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issues 23–24, August 2009, Pages 3978–3985
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us