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Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
8825 607 2009 8 PDF Available
Title
Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles
Abstract

The ability of nitric oxide (NO)-releasing silica nanoparticles to kill biofilm-based microbial cells is reported. Biofilms of Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans were formed in vitro and exposed to NO-releasing silica nanoparticles. Replicative viability experiments revealed that ≥99% of cells from each type of biofilm were killed via NO release, with the greatest efficacy (≥99.999% killing) against gram-negative P. aeruginosa and E. coli biofilms. Cytotoxicity testing demonstrated that the highest dose of NO-releasing silica nanoparticles inhibited fibroblast proliferation to a lesser extent than clinical concentrations of currently administered antiseptics (e.g., chlorhexidine) with proven wound-healing benefits. This study demonstrates the promise of employing nanoparticles for delivering an antimicrobial agent to microbial biofilms.

Keywords
Nitric oxide; Nanoparticle; Biofilm; Antimicrobial; Cytotoxicity
First Page Preview
Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 14, May 2009, Pages 2782–2789
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering