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Silk fibroin/polyacrylamide semi-interpenetrating network hydrogels for controlled drug release

Paper ID Volume ID Publish Year Pages File Format Full-Text
8830 607 2009 11 PDF Available
Title
Silk fibroin/polyacrylamide semi-interpenetrating network hydrogels for controlled drug release
Abstract

The present study describes a semi-interpenetrating network hydrogel fabricated using silk fibroin/polyacrylamide for controlled drug delivery applications. Hydrogels were synthesized using varied ratios of silk fibroin/acrylamide mixtures crosslinked by N,N′-Methylenebisacrylamide. Fourier-Transform Infrared analysis was performed suggesting β sheet transition of silk fibroin with hydrogels. Scanning electron microscopy revealed microporous surface with maximum pore size of 50 ± 11 μm. Rheological properties along with swellability, degradation, sol fraction estimation, equilibrium water content and swelling kinetics were evaluated. Compressive strength of 241.9 ± 5.5 kPa was observed suggesting mechanically stronger gels. MTT assay showed biocompatibility and absence of deleterious effects of hydrogel on cell viability and functionality. In vitro release studies using two model compounds i.e. trypan blue dye and FITC-inulin reveal their sustained release from the fabricated hydrogel constructs.

Keywords
Silk fibroin; Controlled release; Drug delivery; Hydrogel; Semi-interpenetrating networks
First Page Preview
Silk fibroin/polyacrylamide semi-interpenetrating network hydrogels for controlled drug release
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 14, May 2009, Pages 2826–2836
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering