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Control of highly migratory cells by microstructured surface based on transient change in cell behavior

Paper ID Volume ID Publish Year Pages File Format Full-Text
8837 608 2010 7 PDF Available
Title
Control of highly migratory cells by microstructured surface based on transient change in cell behavior
Abstract

Cell migration control techniques have been proposed for cells with relatively low migratory activity, based on static analyses performed with cells that attain a temporally homogenous state after being exposed to a cell guiding stimulus. To elucidate new functions of substrate topography, we investigated the transient change in the behavior of highly migratory cells coming from a flat surface to a grooved surface on a silicon substrate covered with SiO2. A single line groove (1.5 μm in width, 20 μm in depth) and intersecting grooves (1.5 μm in width, 5 μm in spacing, 20 μm in depth) functioned as an effective cell repellent. In the case of wider grooves, a single line groove (4 μm in width; 20 μm in width) had no specified function. In contrast, intersecting grooves (4 μm in width, 5 μm in spacing) functioned as a trap for the cells. Our findings yield a new design concept of cell repelling and trapping surfaces which are applicable to cell guiding methods and single or multiple cell confinement on cell culture substrates, and thus may contribute to development of more advanced biomaterials.

Keywords
Microstructured surface; Microgrooves; Cell-substrate interaction; Cell migration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 33, November 2010, Pages 8539–8545
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us