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The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF

Paper ID Volume ID Publish Year Pages File Format Full-Text
8847 608 2010 8 PDF Available
Title
The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF
Abstract

Spinal cord crushed injury is clinically common. Promoting targeted neural regeneration at the crushed site of spinal cord could be important for the repair. It has been demonstrated in our previous work that native human BDNF fused with a collagen-binding domain (CBD-BDNF) can bind to collagen specifically to exert the neurotrophic effect on promoting axonal regeneration. After injury, collagen is highly accumulated at the injury site. We thus speculate that CBD-BDNF will bind to the extracellular matrix collagen and concentrate at the injury site to improve the therapy. Using the rat spinal cord crushed injury model, we have found that CBD-BDNF by one-time intrathecally injection could be retained and concentrated at the injury site for a longer time than native BDNF without collagen-binding domain. CBD-BDNF could promote better neural regeneration and locomotion recovery.

Keywords
Collagen; Drug delivery; Nerve regeneration; Wound healing
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The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 33, November 2010, Pages 8634–8641
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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