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Effects of small pulsed nanocurrents on cell viability in vitro and in vivo: Implications for biomedical electrodes

Paper ID Volume ID Publish Year Pages File Format Full-Text
8851 608 2010 8 PDF Available
Title
Effects of small pulsed nanocurrents on cell viability in vitro and in vivo: Implications for biomedical electrodes
Abstract

Using a custom-built, implantable pulse generator, we studied the effects of small pulsed currents on the viability on rat aortic-derived cells (RAOC) in vitro. The pulsed currents (0.37 A/m2) underwent apoptosis within 24 h as shown by the positive staining for cleaved caspase-3 and classically apoptotic morphology. Based on these findings, we examined the effects of nanocurrents in vivo. The pulse generator was implanted subcutaneously in the rat model. The electrode|tissue interface histology revealed no difference between the active platinum surface and the neighboring control surface, however we found a large difference between electrodes that were functional during the entire experiment and non-active electrodes. These non-active electrodes showed an increase in impedance at higher frequencies 21 days post-implantation, whereas working electrodes retained their impedance value for the entire experiment. These results indicate that applied currents can reduce the impedance of implanted electrodes.

Keywords
Apoptosis; Cell adhesion; Electrode; Fibrous tissue; Platinum
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Effects of small pulsed nanocurrents on cell viability in vitro and in vivo: Implications for biomedical electrodes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 33, November 2010, Pages 8666–8673
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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