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Skeletal muscle cell proliferation and differentiation on polypyrrole substrates doped with extracellular matrix components

Paper ID Volume ID Publish Year Pages File Format Full-Text
8896 610 2009 13 PDF Available
Title
Skeletal muscle cell proliferation and differentiation on polypyrrole substrates doped with extracellular matrix components
Abstract

Conducting polymers have been developed as substrates for in vitro studies with a range of cell types including electrically-excitable cells such as nerve and smooth muscle. The goal of this study was to optimise and characterise a range of polypyrrole materials to act as substrates for electrical stimulation of differentiating skeletal myoblasts. Although all of the polymer materials provided suitable substrates for myoblast adhesion and proliferation, significant differences became apparent under the low-serum conditions used for differentiation of primary myoblasts. The significance of the work lies in the design and control of polymer materials to facilitate different stages of skeletal muscle cell proliferation and/or differentiation, opening up opportunities for engineering of this tissue. This paper therefore constitutes not just a biocompatibility assessment but a comprehensive study of how synthesis conditions affect the final outcome in terms of cell response.

Keywords
Skeletal muscle; Conducting polymer; Cell differentiation; Cell adhesion; Tissue engineering; Atomic force microscopy
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Skeletal muscle cell proliferation and differentiation on polypyrrole substrates doped with extracellular matrix components
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 29, October 2009, Pages 5292–5304
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us