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Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control

Paper ID Volume ID Publish Year Pages File Format Full-Text
8903 610 2009 12 PDF Available
Title
Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control
Abstract

Effective hemorrhage control becomes increasingly significant in today's military and civilian trauma, and current available local hemostatic agents have been reported to have various drawbacks and side effects. Herein in this study, a silver exchanged calcium doped ordered mesoporous silica sphere (AgCaMSS) with good degradability and antibacterial properties was developed for hemorrhage control. The well-ordered and symmetry hexagonal AgCaMSS with pore size of 3.2 nm, BET surface area of 919 m2/g and pore volume of 0.74 m3/g was prepared by one-step based catalyzed self-assembly and subsequent ion-exchange procedures. The degradation behaviors in Tris–HCl solution indicated that the addition of calcium and silver facilitated the dissolution and the weight loss of the prepared AgCaMSS could attain more than 40% after 42 days. The results obtained demonstrated that the optimal AgCaMSS formulation could significantly promote the blood clotting, activate the intrinsic pathway of coagulation cascade, induce platelet adherence. Consequently, effective hemostasis with low exothermic effects was achieved and the mortalities in femoral artery and liver injury models were reduced. The antibacterial experiment using broth culture method revealed that the prepared AgCaMSS had better antibacterial activities against Escherichia coli and Staphylococcus aureus. Based on these results, it can be concluded that the AgCaMSS developed here would be a promising material platform for designing hemostats in more extensive clinical application.

Keywords
Mesoporous silica sphere; Hemostatic efficiency; Degradation; Antibacterial
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Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 29, October 2009, Pages 5364–5375
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us