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In vivo degradation of low temperature calcium and magnesium phosphate ceramics in a heterotopic model

Paper ID Volume ID Publish Year Pages File Format Full-Text
892 68 2011 7 PDF Available
Title
In vivo degradation of low temperature calcium and magnesium phosphate ceramics in a heterotopic model
Abstract

Bone replacement using synthetic and degradable materials is desirable in various clinical conditions. Most applied commercial materials are based on hydroxyapatite, which is not chemically degradable under physiological conditions. Here we report the effect of a long-term intramuscular implantation regime on the dissolution of various low temperature calcium and magnesium phosphate ceramics in vivo. The specimens were analysed by consecutive radiographs, micro-computed tomography scans, compressive strength testing, scanning electron microscopy and X-ray diffractometry. After 15 months in vivo, the investigated materials brushite (CaHPO4·2H2O), newberyite (MgHPO4·3H2O), struvite (MgNH4PO4·6H2O) and hydroxyapatite (Ca9(PO4)5HPO4OH) showed significant differences regarding changes of their characteristics. Struvite presented the highest loss of mechanical performance (95%), followed by newberyite (67%) and brushite (41%). This was accompanied by both a distinct extent of cement dissolution as well as changes of the phase composition of the retrieved cement implants. While the secondary phosphate phases (brushite, newberyite, struvite) completely dissolved, re-precipitates of whitlockite and octacalcium phosphate were formed in either particulate or whisker-like morphology. Furthermore, for the first time the possibility of a macropore-free volume degradation mechanism of bioceramics was demonstrated.

Keywords
Bone replacement material; Calcium magnesium phosphate cement; Newberyite; Struvite; Brushite
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In vivo degradation of low temperature calcium and magnesium phosphate ceramics in a heterotopic model
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 9, September 2011, Pages 3469–3475
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us