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The effect of electrical stimulation on the differentiation of hESCs adhered onto fibronectin-coated gold nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
8932 610 2009 8 PDF Available
Title
The effect of electrical stimulation on the differentiation of hESCs adhered onto fibronectin-coated gold nanoparticles
Abstract

To encourage stem cell differentiation, gold nanoparticles (20 nm) were used to deliver electrical stimulation to human embryonic stem cells (hESCs) in vitro. Nano-structured gold nanoparticles were designed by coating the surface of culture dishes with gold nanoparticles using a layer-by-layer (LBL) system. In this method, gold nanoparticles were continuously coated onto dishes by SEM analysis. Evaluation of gene modified hESCs that were subsequently attached onto fibronectin-coated gold nanoparticles revealed that the un-differentiation marker, Oct-4, was no longer present following electrical stimulation. In addition, the osteogenic markers of collagen type I and Cbfa1 increased in response to electrical stimulation, while those of hESCs were not observed without electrical stimulation.

Keywords
Stem cell differentiation; Gold nanoparticles; hESCs; Gene modified hESCs; Electrical stimulation
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The effect of electrical stimulation on the differentiation of hESCs adhered onto fibronectin-coated gold nanoparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 29, October 2009, Pages 5631–5638
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us