fulltext.study @t Gmail

Solvothermal synthesis of cobalt ferrite nanoparticles loaded on multiwalled carbon nanotubes for magnetic resonance imaging and drug delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
895 68 2011 9 PDF Available
Title
Solvothermal synthesis of cobalt ferrite nanoparticles loaded on multiwalled carbon nanotubes for magnetic resonance imaging and drug delivery
Abstract

Multiwalled carbon nanotube (MWCNT)/cobalt ferrite (CoFe2O4) magnetic hybrids were synthesized by a solvothermal method. The reaction temperature significantly affected the structure of the resultant MWCNT/CoFe2O4 hybrids, which varied from 6 nm CoFe2O4 nanoparticles uniformly coated on the nanotubes at 180 °C to agglomerated CoFe2O4 spherical particles threaded by MWCNTs and forming necklace-like nanostructures at 240 °C. Based on the superparamagnetic property at room temperature and high hydrophilicity, the MWCNT/CoFe2O4 hybrids prepared at 180 °C (MWCNT/CoFe2O4-180) were further investigated for biomedical applications, which showed a high T2 relaxivity of 152.8 Fe mM−1 s−1 in aqueous solutions, a significant negative contrast enhancement effect on cancer cells and, more importantly, low cytotoxicity and negligible hemolytic activity. The anticancer drug doxorubicin (DOX) can be loaded onto the hybrids and subsequently released in a sustained and pH-responsive way. The DOX-loaded hybrids exhibited notable cytotoxicity to HeLa cancer cells due to the intracellular release of DOX. These results suggest that MWCNT/CoFe2O4-180 hybrids may be used as both effective magnetic resonance imaging contrast agents and anticancer drug delivery systems for simultaneous cancer diagnosis and chemotherapy.

Graphical abstractMultiwalled carbon nanotube/CoFe2O4 nanocomposites with superparamagnetic property and high hydrophilicity have been successfully synthesized by an in situ solvothermal method at 180 °C for MRI and anticancer drug delivery applications.Figure optionsDownload full-size imageDownload high-quality image (179 K)Download as PowerPoint slide

Keywords
Carbon nanotubes; Cobalt ferrite; Solvothermal method; Magnetic resonance imaging; Drug delivery
First Page Preview
Solvothermal synthesis of cobalt ferrite nanoparticles loaded on multiwalled carbon nanotubes for magnetic resonance imaging and drug delivery
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 9, September 2011, Pages 3496–3504
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering