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The toxicokinetics and distribution of 2-hydroxyethyl methacrylate in mice

Paper ID Volume ID Publish Year Pages File Format Full-Text
8971 611 2009 6 PDF Available
Title
The toxicokinetics and distribution of 2-hydroxyethyl methacrylate in mice
Abstract

The cytotoxicity of dental composites has been attributed to the release of residual monomers from polymerized resin-based composites due to the degradation processes or the incomplete polymerisation of materials. 2-Hydroxyethyl methacrylate (HEMA) is one of the major components released from dental resin-based composites. It was shown in vitro that HEMA was released into the adjacent biophase from such materials during the first days after placement. In this study uptake, distribution, and excretion of 14C-HEMA applied via gastric tube or subcutaneous administration at dose levels well above those encountered in dental care were examined in mice to test the hypothesis that HEMA can reach cytotoxic levels in mammalian tissues. 14C-HEMA was taken up rapidly from the stomach and intestines after gastric administration and was widely distributed in the body following administration by each route. Most 14C was excreted within one day as 14CO2. Two metabolic pathways of 14C-HEMA can be described. The peak HEMA levels in all tissues examined after 24 h were lower than known toxic levels. Therefore the study did not support the hypothesis.

Keywords
Dental restorative material; Biocompatibility; Biodegradation; Composite
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The toxicokinetics and distribution of 2-hydroxyethyl methacrylate in mice
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 11, April 2009, Pages 2066–2071
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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Any Questions? feel free to contact us