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Periprosthetic tissue reactions observed at revision of total intervertebral disc arthroplasty

Paper ID Volume ID Publish Year Pages File Format Full-Text
8973 611 2009 6 PDF Available
Title
Periprosthetic tissue reactions observed at revision of total intervertebral disc arthroplasty
Abstract

Wear, wear particle induced inflammation, and osteolysis following total disc arthroplasty were, until recently, not thought to be present due to limited intervertebral motion and the lack of a synovial membrane between the lower lumbar vertebrae. The purpose of this study was to evaluate the periprosthetic tissue reactions associated with total disc arthroplasty revision surgery. Periprosthetic samples of fibrous tissue were collected in all patients during revision surgery of SB Charité III disc prostheses. Revision was indicated for intractable pain after an average of 8 years. Histological evaluation was performed in tissue samples of 16 patients using light microscopy and polarized light microscopy with a magnification of 100×. Polyethylene particles were detected in 15 of 16 patients. The smallest particles were the most numerate. A positive correlation was present between the number of particles per mm2 and the extent of the chronic inflammatory reaction in the periprosthetic fibrous tissue. Osteolysis was observed in one patient. In the tissue samples containing polyethylene particles, TNF-α and IL-6 were determined by immunohistochemistry. TNF-α and IL-6 were co-expressed as a subset of mononuclear macrophages and giant cells.

Keywords
Total disc arthroplasty; Charité; Lumbar spine; Polyethylene wear; Inflammation
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Periprosthetic tissue reactions observed at revision of total intervertebral disc arthroplasty
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 11, April 2009, Pages 2079–2084
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us