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Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers

Paper ID Volume ID Publish Year Pages File Format Full-Text
9042 615 2009 9 PDF Available
Title
Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers
Abstract

An artificial oxygen carrier is constructed by conjugating hemoglobin molecules to biodegradable micelles. Firstly a series of triblock copolymers (PEG–PMPC–PLA) in which the middle block contains pendant propargyl groups were synthesized and characterized. After the amphiphilic copolymer was self-assembled into core-shell micelles in aqueous solution, azidized hemoglobin molecules protected by carbon monoxide (CO) were conjugated to the micelles via click reaction between the propargyl and azido groups. The conjugation causes an increase of the micelle's mean diameter. Maximum conjugation ratio is 250 wt% in the hemoglobin-conjugated micelles (HCMs). Oxygen-binding ability of the HCMs was demonstrated by converting the CO-binding state of the HCMs into O2-binding state.

Keywords
Hemoglobin; Artificial oxygen carrier; Red blood cells; Micelles
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Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 28, October 2009, Pages 5077–5085
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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