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Calcium alginate beads embedded in silk fibroin as 3D dual drug releasing scaffolds

Paper ID Volume ID Publish Year Pages File Format Full-Text
9052 615 2009 8 PDF Available
Title
Calcium alginate beads embedded in silk fibroin as 3D dual drug releasing scaffolds
Abstract

3D scaffolds based on embedding drug loaded calcium alginate beads within silk fibroin protein were fabricated for investigating controlled dual drug release. The 3D matrices were evaluated for in vitro release using two different molecular weight model compounds, bovine serum albumin (66 kDa) and FITC–Inulin (3.9 kDa). The model compound release profiles revealed dependence on molecular weight of encapsulated model drugs for sustained release. Further, silk fibroin protein blended calcium alginate beads resulted in prolonged drug release without initial bursts for 35 days as compared to calcium alginate beads without silk fibroin as control. The release kinetics were further tested as a function of wt% silk content for scaffold fabrication suggesting their possible role in restricting initial burst and leading to sustainable release of compounds for prolong time. Silk coatings on calcium alginate beads provided mechanically stable shells as well as a diffusion barrier to the encapsulated protein drugs thus controlling their release. Scanning electron microscopic observations were carried out to assess cellular viability and biocompatibility of bead embedded-silk 3D scaffolds using fibroblast cells. The results highlight the versatile and tunable properties of calcium alginate embedded fibroin 3D scaffolds making them exciting candidate for the controlled release of a wide spectrum of bioactive molecules from a single delivery vehicle.

Keywords
Silk fibroin; Scaffolds; Drug delivery; Controlled release; Tissue engineering
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Calcium alginate beads embedded in silk fibroin as 3D dual drug releasing scaffolds
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 28, October 2009, Pages 5170–5177
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us