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Biodegradable poly(polyol sebacate) polymers

Paper ID Volume ID Publish Year Pages File Format Full-Text
9063 616 2008 10 PDF Available
Title
Biodegradable poly(polyol sebacate) polymers
Abstract

We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's moduli ranging from 0.37 ± 0.08 to 378 ± 33 MPa with maximum elongations at break from 10.90 ± 1.37% to 205.16 ± 55.76%, and glass transition temperatures ranging from ∼7–46 °C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(l-lactic-co-glycolic acid) (PLGA).

Keywords
Biomaterial; Poly(polyol sebacate); Polyol; Polymer; Biodegradable
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 36, December 2008, Pages 4726–4735
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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