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Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
9073 616 2008 8 PDF Available
Title
Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy
Abstract

Nanoscale therapeutic interventions are increasingly important elements in the portfolio of cancer therapeutics. The efficacy of nanotherapeutics is dictated, in part, by the access they have to tumors via the leaky tumor vasculature. Yet, the extent of tumor vessel leakiness in individual tumors varies widely resulting in a correspondingly wide tumor dosing and resulting range of responses to therapy. Here we report the design of a multifunctional nanocarrier that simultaneously encapsulates a chemotherapeutic and a contrast agent which enables a personalized nanotherapeutic approach for breast cancer therapy by permitting tracking of the nanocarrier distribution by mammography, a widely used imaging modality. Following systemic administration in a rat breast tumor model, imaging demonstrated a wide range of intratumoral deposition of the nanocarriers, indicating variable tumor vessel leakiness. Notably, specific tumors that exhibited high uptake of the nanocarrier as visualized by imaging were precisely the animals that responded best to the treatment as quantified by low tumor growth and prolonged survival.

Keywords
Mutlifunctional nanoparticle; Personalized medicine; Iodine-doxorubicin-loaded liposome; Breast cancer imaging; Prediction of chemotherapy
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Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 36, December 2008, Pages 4815–4822
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us