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Factors influencing osteoblast maturation on microgrooved titanium substrata

Paper ID Volume ID Publish Year Pages File Format Full-Text
9086 617 2010 12 PDF Available
Title
Factors influencing osteoblast maturation on microgrooved titanium substrata
Abstract

In this study, we demonstrate surfaces with various dimensions of microgrooves fabricated by photolithography and subsequent acid etching that enhance various characteristics of titanium. Microgrooves with truncated V-shape in cross-section from 15 to 90 μm widths enabled us to report their exclusive effects on altering the surface chemistry and on enhancing the surface hydrophilicity, serum protein adsorption and osteoblast maturation on titanium substrata in a microgroove dimension-dependent manner. Further, acid etching and measurement direction separately affected the surface hydrophilicity results. By multiple correlation and regression analyses, surface chemistry, surface hydrophilicity and serum protein adsorption were determined to be the significant influential factors on osteoblast maturation. Within the limitations of this study, we conclude that combined submicron- and microtopography with relevant micro-dimension and structure enhance various characteristics of titanium, including surface hydrophilicity, which act as the essential factors influencing the osteoblast maturation on microgrooved titanium substrata.

Keywords
Surface topography; Surface analysis; Hydrophilicity; Protein adsorption; Osteoblast
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 14, May 2010, Pages 3804–3815
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us