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Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing Vitamin E diffusion barriers

Paper ID Volume ID Publish Year Pages File Format Full-Text
9110 617 2010 16 PDF Available
Title
Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing Vitamin E diffusion barriers
Abstract

This paper proposes an approach for increasing drug release durations from contact lenses and other biomedical devices by in situ creation of transport barriers of Vitamin E that force drug molecules to diffuse through long tortuous path. Results show that the increase in release duration is quadratic in Vitamin E loading, which is consistent with proposed mathematical models. Loadings of 10 and 40% Vitamin E increase release time of timolol by a factor of about 5 and 400, respectively for NIGHT&DAY™ lens. Similar results have been obtained for other hydrophilic drugs including fluconazole and dexamethasone 21-disodium phosphate (DXP). Vitamin E loading in the NIGHT&DAY™ lens leads to slight increase in lens sizes (6.5% increase for 30% loading), a slight reduction in oxygen diffusion (about 40% reduction for 75% loading), and a more significant reduction in the ion permeability (50% reduction for 10% loading). Additionally, Vitamin E loading has a beneficial effect of blocking UV radiation which will reduce the corneal damage due to UV light.

Keywords
Silicone contact lens; Vitamin E; Diffusion barriers; Extended release; Ophthalmic drug delivery
First Page Preview
Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing Vitamin E diffusion barriers
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 14, May 2010, Pages 4032–4047
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering