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Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents

Paper ID Volume ID Publish Year Pages File Format Full-Text
9155 618 2010 8 PDF Available
Title
Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents
Abstract

The objective of this study was to develop radiopaque iodinated emulsions for use as CT blood pool contrast agents. Three hydrophobic iodinated oils were synthesized based on the 2,3,5-triiodobenzoate moiety and formulated into emulsions using either phospholipids or amphiphilic polymers, i.e. Pluronic F68 and poly(butadiene)-b-poly(ethylene glycol) (PBD-PEO), as emulsifiers. The size, stability and cell viability was investigated for all stabilized emulsions. Three emulsions stabilized with either lipids or PBD-PEO were subsequently tested in vivo as a CT blood pool contrast agent in mice. While the lipid-stabilized emulsions turned out unstable in vivo, polymer-stabilized emulsions performed well in vivo. In blood, a contrast enhancement of 220 Hounsfield Units (HU) was measured directly after intravenous administration of 520 mg I/kg. The blood circulation half-life of a PBD-PEO stabilized emulsion was approximately 3 h and no noticeable in vivo toxicity was observed. These results show the potential of above emulsions for use as blood pool agents in contrast enhanced CT imaging.

Keywords
Computed tomography (CT); Contrast agent; Emulsion; Nanoparticles; Iodine; X-ray imaging
First Page Preview
Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 25, September 2010, Pages 6537–6544
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering