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The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation

Paper ID Volume ID Publish Year Pages File Format Full-Text
9172 619 2009 5 PDF Available
Title
The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation
Abstract

In this study we investigate the effects of nanotubular titanium oxide (TiO2) surfaces on vascular cells. EC and VSMC response to nanotubes was investigated through immunofluorescence staining, scanning electron microscopy, 5-ethynyl-2′-deoxyuridine proliferation assays, and prostaglandin I2 (PGI2) enzyme immunoassays. We found that the nanotubular surface significantly enhances EC proliferation and secretion of PGI2. The surface also results in a decrease in VSMC proliferation and increased expression of smooth muscle α-actin. These data suggest that engineered nanotopographical cues may influence both EC and VSMC behavior in a manner that may be useful for stent or other vascular applications.

Keywords
Endothelial cell; Vascular smooth musle cell; Nanotopography
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The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 7, March 2009, Pages 1268–1272
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us