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Alginate–lanthanide microspheres for MRI-guided embolotherapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
922 69 2013 7 PDF Available
Title
Alginate–lanthanide microspheres for MRI-guided embolotherapy
Abstract

In cancer therapy, a promising treatment option to accomplish a high tumor-to-normal-tissue ratio is endovascular intervention with microsized particles, such as embolotherapy. In this study, alginate microspheres (ams) were prepared with the JetCutter technique, which is based on cutting a sodium alginate solution jet stream into small droplets of uniform size which are then cross-linked with different lanthanides or iron-III, resulting in microspheres of a predefined size which can be visualized by magnetic resonance imaging (MRI). The microspheres were investigated for their size and morphology (light microscopy and scanning electron microscopy analysis), cation content and MRI properties. The lanthanide-ams formulations, with a uniform size of 250 μm and a cation content between 0.72–0.94%, showed promising results for MR imaging. This was further demonstrated for Ho3+-cross-linked alginate microspheres (Ho3+-ams), the most potent microsphere formulation with respect to MR visualization, allowing single sphere detection and detailed microsphere distribution examination. Intravascular infusion of Ho3+-ams by catherization of ex vivo rabbit and porcine liver tissue and assessment of the procedure with MRI clearly showed accumulation and subsequently embolization of the targeted vessels, allowing accurate monitoring of the microsphere biodistribution throughout the tissue. Therefore, the different alginate–lanthanide microsphere formulations developed in this study show great potential for utilization as image-guided embolotherapy agents.

Graphical abstractThe JetCutter system used in this study to prepare monodisperse alginate microspheres which can be visualized by MRI.Figure optionsDownload full-size imageDownload high-quality image (163 K)Download as PowerPoint slide

Keywords
Alginate; Microspheres; Embolotherapy; Magnetic resonance imaging; JetCutter technique
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Alginate–lanthanide microspheres for MRI-guided embolotherapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 1, January 2013, Pages 4681–4687
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us