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ZnO QD@PMAA-co-PDMAEMA nonviral vector for plasmid DNA delivery and bioimaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
9242 622 2010 8 PDF Available
Title
ZnO QD@PMAA-co-PDMAEMA nonviral vector for plasmid DNA delivery and bioimaging
Abstract

Low cytotoxic ZnO quantum dot-based nonviral vectors with the dual functions of delivering plasmid DNA and labeling cells were fabricated by capping the surface of ZnO QD with poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA), which was synthesized in situ by radical polymerization. The polycation-modified ZnO QDs were capable of condensing plasmid DNA into nanocomplexes (Qdotplexes) loaded with ZnO QDs emitting strong yellow luminescence under UV light. The Qdotplexes could mediate an efficient transfer of plasmid DNA into COS-7 cells with much lower cytotoxicity, meanwhile allowing real-time imaging of gene transfection.

Keywords
DNA condensation; Gene transfection; Plasmid DNA; Quantum dots; ZnO
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ZnO QD@PMAA-co-PDMAEMA nonviral vector for plasmid DNA delivery and bioimaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 11, April 2010, Pages 3087–3094
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us