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Multiarm cationic star polymers by atom transfer radical polymerization from β-cyclodextrin cores: Influence of arm number and length on gene delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
927 69 2013 8 PDF Available
Title
Multiarm cationic star polymers by atom transfer radical polymerization from β-cyclodextrin cores: Influence of arm number and length on gene delivery
Abstract

Controlled β-cyclodextrin (β-CD) core-based cationic star polymers have attracted considerable attention as non-viral gene carriers. Atom transfer radical polymerization (ATRP) could be readily used to produce the star-shaped polymers. The precise control of the number of initiation sites on the multifunctional core was of crucial importance to the investigation of the structure–property relationship of the functional star gene carriers. Herein, the controlled multiarm star polymers consisting of a β-CD core and various arm lengths of poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) were prepared via ATRP from the chloroacetylated β-CD with well-designed initiation sites. Generally, these star polycations can condense plasmid DNA into 100–150 nm nanoparticles with positive zeta potentials of 30–40 mV at N/P ratios (star polymer to DNA ratios) of 17 or higher. The effects of arm numbers and lengths on gene delivery were investigated in detail. With a fixed length of the PDMAEMA arm, the fewer the number of arms, the lower the toxicity. The star polycations with suitable arm numbers possess the best transfection ability. On the other hand, with the fixed molecular weights, the shorter the arms, the lower the toxicity. The polymers with 21 arms possess the lowest transfection efficiency.

Keywords
Gene delivery; Star-shaped polycation; β-CD; ATRP; DMAEMA
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Multiarm cationic star polymers by atom transfer radical polymerization from β-cyclodextrin cores: Influence of arm number and length on gene delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 1, January 2013, Pages 4726–4733
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us