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Cytotoxic aspects of gadolinium oxide nanostructures for up-conversion and NIR bioimaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
928 69 2013 10 PDF Available
Title
Cytotoxic aspects of gadolinium oxide nanostructures for up-conversion and NIR bioimaging
Abstract

Bioimaging is an important diagnostic tool in the investigation and visualization of biological phenomena in cells and in medicine. In this context, up-converting Gd2O3:Er3+,Yb3+ nanostructures (nanoparticles, nanorods) have been synthesized by precipitation methods and hydrothermal synthesis. Independent of size and morphology, Gd2O3:Er3+,Yb3+ powders show up-conversion (550 nm, 670 nm) and near-infrared emission (1.5 μm) upon 980 nm excitation, which makes these structures interesting for application as biomarkers. With regard to their potential application in bioimaging, cytotoxicity is an important aspect and is strongly affected by the physico-chemical properties of the investigated nanostructures. Therefore, the cytotoxic effect of bare and poly(ethylene glycol)-b-poly(acrylic acid) block co-polymer-modified nanostructures on non-phagocytic and phagocytic cells (B-cell hybridoma cells and macrophages) was investigated. The observed cytotoxic behavior in the case of macrophages incubated with bare nanostructures was assigned to the poor chemical durability of gadolinium oxide, but could be overcome by surface modification.

Graphical abstractGadolinium oxide nanorods and particles doped with Er3+ and Yb3+ are synthesized by hydrothermal and precipitation method. Under excitation in the near-infrared range (980 nm), obtained structures show upconversion (550 nm, 660 nm) as well as NIR emission (1.5 μm) which makes them interesting candidates for NIR-NIR bioimaging applications. The relationship between physico-chemical properties of bare and PEG-modified powders and their cytotoxicity is investigated.Figure optionsDownload full-size imageDownload high-quality image (107 K)Download as PowerPoint slide

Keywords
Gadolinium oxide; Near-infrared emission; Bioimaging; Surface modification; Cytotoxicity
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Cytotoxic aspects of gadolinium oxide nanostructures for up-conversion and NIR bioimaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 1, January 2013, Pages 4734–4743
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us