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A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid–poly(ethylene glycol) and macrophage uptake

Paper ID Volume ID Publish Year Pages File Format Full-Text
929 69 2013 10 PDF Available
Title
A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid–poly(ethylene glycol) and macrophage uptake
Abstract

Amphiphilic lipid–poly(ethylene glycol) (LPEG) is widely used for the noncovalent functionalization of graphene nanomaterials (GNMs) to improve their dispersion in aqueous solutions for biomedical applications. However, not much is known about the detachment of LPEGs from GNMs and macrophage uptake of dispersed GNMs in relation to the alkyl chain coverage, the PEG coverage, and the linker group in LPEGs. In this study we examined these relationships using single walled carbon nanohorns (SWCNHs). The high coverage of PEG rather than that of alkyl chains was dominant in suppressing the detachment of LPEGs from SWCNHs in protein-containing physiological solution. Correspondingly, the quantity of LPEG-covered SWCNHs (LPEG-SWCNHs) taken up by macrophages decreased at a high PEG coverage. Our study also demonstrated an effect of the ionic group in LPEG on SWCNH uptake into macrophages. A phosphate anionic group in the LPEG induced lower alkyl chain coverage and easy detachment of the LPEG, however, the negative surface charge of LPEG-SWCNHs reduced the uptake of SWCNHs by macrophages.

Graphical abstractThe dispersion effectiveness of different lipid-PEGs (LPEGs) for the single-walled carbon nanohorns (SWCNHs) were discussed with the chemical structures and LPEG coverage. They were also related with the LPEG detachment from SWCNH and cellular uptake of LPEG-SWNHs.Figure optionsDownload full-size imageDownload high-quality image (112 K)Download as PowerPoint slide

Keywords
Single-walled carbon nanohorn; Noncovalent functionalization; Lipid–poly(ethylene glycol); Detachment; Macrophage uptake
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A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid–poly(ethylene glycol) and macrophage uptake
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 1, January 2013, Pages 4744–4753
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us