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The biocompatibility of quantum dot probes used for the targeted imaging of hepatocellular carcinoma metastasis

Paper ID Volume ID Publish Year Pages File Format Full-Text
9302 625 2008 7 PDF Available
Title
The biocompatibility of quantum dot probes used for the targeted imaging of hepatocellular carcinoma metastasis
Abstract

Semiconductor quantum dots (QDs) have several photo-physical advantages over organic dyes making them good markers in biomedical application. We used CdSe/ZnS QDs with maximum emission wavelength of 590 nm (QD590) linked to alpha-fetoprotein (AFP) monoclonal antibody (Ab) to detect AFP in cytoplasm of human hepatocellular carcinoma (HCC) cell line HCCLM6. For the in vivo studies, we used QD–AFP–Ab probes for targeted imaging of human HCC xenograft growing in nude mice by injecting them into the tail vein. In addition, the cytotoxicity in vitro, the acute toxicity in vivo, the hemodynamics and tissue distribution of these probes were also investigated. The results in vitro and in vivo indicate that our QD-based probes have good stability, specificity and biocompatibility for ultrasensitive fluorescence imaging of molecular targets in our liver cancer model system.

Keywords
Quantum dots; Hepatocellular carcinoma; Metastasis; Toxicity; Biocompatibility
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The biocompatibility of quantum dot probes used for the targeted imaging of hepatocellular carcinoma metastasis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 31, November 2008, Pages 4170–4176
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us