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Functionalizable and ultra-low fouling zwitterionic surfaces via adhesive mussel mimetic linkages

Paper ID Volume ID Publish Year Pages File Format Full-Text
9332 627 2010 7 PDF Available
Title
Functionalizable and ultra-low fouling zwitterionic surfaces via adhesive mussel mimetic linkages
Abstract

In this work, a biomimetic polymer (pCB2-catechol2), with two zwitterionic poly(carboxybetaine) (pCB) arms for ultra-low fouling and two adhesive catechol groups for surface anchoring, was developed. Two pCB arms were grown from an initiator with two catechol groups via atom transfer radical polymerization (ATRP). Binding tests of pCB2-catechol2 were performed on a gold surface under a range of conditions such as pH values and solvents. Protein adsorption from single protein solutions of fibrinogen and lysozyme, and complex media of 100% blood plasma and serum was evaluated using a surface plasmon resonance (SPR) sensor. Results are compared with those from two other polymers (i.e., one polymer with one pCB chain and one catechol group, termed as pCB-catechol, and another polymer with one pCB chain and two catechol groups, termed as pCB-catechol2). Furthermore, the direct immobilization of anti-activated leukocyte cell adhesion molecule (anti-ALCAM) was carried out on the pCB2-catechol2 modified surface. Results showed that the antibody-immobilized surface maintained its excellent ultra-low fouling properties. The detection of activated leukocyte cell adhesion molecule (ALCAM) in 100% blood plasma with high sensitivity and specificity was achieved. This work demonstrates an effective and convenient strategy to obtain functionalizable and ultra-low fouling surfaces.

Keywords
Zwitterionic; Catechol; Nonfouling; Functionalization
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Functionalizable and ultra-low fouling zwitterionic surfaces via adhesive mussel mimetic linkages
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 7, March 2010, Pages 1486–1492
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us