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Sentinel lymph node mapping by a near-infrared fluorescent heptamethine dye

Paper ID Volume ID Publish Year Pages File Format Full-Text
9380 627 2010 7 PDF Available
Title
Sentinel lymph node mapping by a near-infrared fluorescent heptamethine dye
Abstract

We describe a near-infrared fluorescent heptamethine dye (IR-780 iodide) with unique properties for sentinel lymph node (SLN) mapping in both small and large animals. This dye has a significant photobrightening effect in serum and a long retention time in the lymphatic system which allows to acquire much higher signal-to-noise ratios. Injection of only 10 nmol of this dye permits SLNs to be imaged easily in pigs using excitation fluence rates of only 2 μW/cm2. In addition, this dye has a unique stability property after formalin fixation in tissues which raises the possibility of developing new and sensitive means of detecting lymph nodes in harvested surgical specimens. This dye can be completely cleared from the circulation in a couple of days and does not cause acute systemic toxicity.

Keywords
In vivo test; Fluorescence; Sentinel lymph node; Mapping; Heptamethine dye
First Page Preview
Sentinel lymph node mapping by a near-infrared fluorescent heptamethine dye
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 7, March 2010, Pages 1911–1917
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering