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Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses

Paper ID Volume ID Publish Year Pages File Format Full-Text
939 69 2013 9 PDF Available
Title
Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses
Abstract

Mesoporous bioactive glass scaffolds (MBG_Scs), based on 80% SiO2–15% CaO–5% P2O5 (in mol.%) mesoporous sol–gel glasses substituted with Ce2O3, Ga2O3 (both 0.2% or 1.0%) and ZnO (0.4% or 2.0%), were synthesized by combination of evaporation-induced self-assembly and rapid prototyping techniques. Cerium, gallium and zinc trace elements were selected because of their inherent beneficial biological properties. Fabricated scaffolds were characterized and compared with unsubstituted scaffold (B_Sc). All of them contained well interconnected ultralarge pores (pores >400 μm) ideal for vascular ingrowth and proliferation of cells. Macropores of size 100–400 μm were present inside the scaffolds. In addition, low-angle X-ray diffraction showed that B_Sc and scaffolds with substituent contents up to 0.4% exhibited ordered mesoporosity useful for hosting molecules with biological activity. The textural properties of B_Sc were a surface area of 398 m2 g−1, a pore diameter of 4.3 nm and a pore volume of 0.43 cm3 g−1. A slight decrease in surface area and pore volume was observed upon substitution with no distinct effect on pore diameter. In addition, all the MBG_Scs except 2.0% ZnO_Sc showed quite quick in vitro bioactive response. Hence, the present study is a positive addition to ongoing research into preparing bone tissue engineering scaffolds from bioceramics containing elements of therapeutic significance.

Graphical abstractMesoporous bioactive glass scaffolds in the SiO2–CaO–P2O5–X systems (X= cerium, gallium or zinc oxides) were synthesized by combination of evaporation induced self assembly and rapid prototyping techniques. Designed scaffolds exhibited high in vitro bioactivity and adequate textural properties as shown by the parent MBGs. In addition, they possess ultra large pores suitable for bone cell growth, proliferation and vascularization with added biological features of substituents.Figure optionsDownload full-size imageDownload high-quality image (341 K)Download as PowerPoint slide

Keywords
Scaffolds with hierarchical porosity; Mesoporous glasses with Ce2O3, Ga2O3 or ZnO; Rapid prototyping; In vitro bioactivity; Bone tissue engineering
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Mesoporous bioactive scaffolds prepared with cerium-, gallium- and zinc-containing glasses
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 9, Issue 1, January 2013, Pages 4836–4844
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us