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The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid–tyramine composite as an injectable bone cement

Paper ID Volume ID Publish Year Pages File Format Full-Text
9426 629 2009 7 PDF Available
Title
The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid–tyramine composite as an injectable bone cement
Abstract

We have developed an injectable bone cement composed of nanocrystalline apatite and crosslinked hyaluronic acid–tyramine conjugates (HA–Tyr). This bone cement was formed via the oxidative coupling of tyramine moieties catalyzed by hydrogen peroxide (H2O2) and horseradish peroxidise (HRP). The bone cement set within 60 s after H2O2 and HRP were added to the apatite/HA–Tyr pastes. The mechanical strength of the apatite/HA–Tyr cement was tuned by varying the apatite loading and H2O2 concentration. This rapid enzyme-mediated setting of our bone cement results in minimal heat release (ΔH = −11.39 J/g) as compared to conventional bone cements. The crystalline phase and crystallite size (20 nm) of the apatitic phase in our bone cement matched that of trabecular bone. The storage modulus (G′), yield stress (σy), and compressive stiffness (Ec) of our bone cement prepared with different apatite loadings and H2O2 concentrations were measured, and optimized at G′ = 40 MPa, σy = 0.308 MPa and Ec = 2.270 MPa when the cement was formed with 0.4 g/ml of apatite, 0.61 units/ml of HRP and 6.8 mm of H2O2. Our biocompatible bone cement also successfully healed small bone and joint defects in mice within 8 weeks.

Keywords
Biomimetic material; Bone healing; Hydroxyapatite; Nanocomposite; Scaffold
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The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid–tyramine composite as an injectable bone cement
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 5, February 2009, Pages 822–828
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us