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Imaging the disruption of phospholipid monolayer by protein-coated nanoparticles using ordering transitions of liquid crystals

Paper ID Volume ID Publish Year Pages File Format Full-Text
9429 629 2009 7 PDF Available
Title
Imaging the disruption of phospholipid monolayer by protein-coated nanoparticles using ordering transitions of liquid crystals
Abstract

We report an easily visualized liquid crystal (LC)-based system to study the molecular interactions between protein-coated gold nanoparticles (AuNPs) and supported phospholipid monolayer self-assembled at the aqueous-LC interface. Protein-coated AuNPs were found to disrupt the phospholipid monolayer and resulted in the orientational transitions of LCs that support the phospholipid layer. The disruption of the phospholipid monolayer depends on the type of protein (albumin, neutravidin, and fibrinogen) adsorbing onto nanoparticles. Furthermore, our results suggest that hydrophobic interaction plays a major role in the disruption of the phospholipid layer by protein-coated AuNPs. Results obtained from this study may offer new understanding in the potential cytotoxicity of nanomaterials, where the interaction between nanoparticles and cell membrane is an important step.

Keywords
Phospholipids; Gold nanoparticles; Liquid crystals; Proteins; Hydrophobic interactions
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Imaging the disruption of phospholipid monolayer by protein-coated nanoparticles using ordering transitions of liquid crystals
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 5, February 2009, Pages 843–849
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us