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Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals

Paper ID Volume ID Publish Year Pages File Format Full-Text
9455 630 2008 7 PDF Available
Title
Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals
Abstract

Here we report the synthesis of uniform silica coated hexagonal-phase NaYF4 nanocrystals with strong NIR-to-visible upconversion fluorescence and its cytotoxicity and biodistribution in a rat model. The silica coated NaYF4 nanocrystals were incubated with rat skeletal myoblasts and bone marrow-derived mesenchymal stem cells and cytotoxicity was assessed by using MTS and LDH assay. Healthy rats were injected intravenously with the nanocrystals so as to further investigate their biocompatibility and tissue distribution. The results from this study revealed that the silica coated NaYF4 upconversion nanocrystals displayed good in vitro and in vivo biocompatibility, demonstrating their potential applications in both cellular and animal imaging systems.

Keywords
Near infrared; Upconversion nanocrystals; Imaging; Toxicity; Biodistribution
First Page Preview
Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 30, October 2008, Pages 4122–4128
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering