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The in vitro biocompatibility of self-assembled hyperbranched copolyphosphate nanocarriers

Paper ID Volume ID Publish Year Pages File Format Full-Text
9510 633 2010 9 PDF Available
Title
The in vitro biocompatibility of self-assembled hyperbranched copolyphosphate nanocarriers
Abstract

Polymeric micelles are recognized as very promising nanocarriers for small-molecule drugs, DNA, and proteins delivery. Polyphosphates are an important class of eminent biomaterials and widely used in biomedicine due to their good biocompatibility, biodegradability, and flexibility in adjusting the pendant structures. Here, some full-polyphosphate nanocarriers have been constructed successfully through self-assembly of amphiphilic hyperbranched multiarm copolymers (denoted as HPHEEP-star-PPEPs). The hydrophilic core and hydrophobic multiarm of HPHEEP-star-PPEPs are composed by hyperbranched and linear polyphosphates respectively. HPHEEP-star-PPEPs can self-assembly into nanocarriers in aqueous media with controlled size from 48 to 74 nm by conveniently adjusting the length of hydrophobic arm. These nanocarriers possess excellent biocompatibility against NIH 3T3 cells and are easily internalized by vivid cells. Chlorambucil-loaded nanocarriers were investigated for proliferation inhibition of an MDA-MB-231 breast cancer cell line in vitro, and the chlorambucil dose required for 50% cellular growth inhibition was found to be 3 μg/mL.

Keywords
Polyphosphate; Nanocarrier; Self-assembly; Hyperbranched polymer; Biocompatibility
First Page Preview
The in vitro biocompatibility of self-assembled hyperbranched copolyphosphate nanocarriers
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 21, July 2010, Pages 5643–5651
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering