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Pore size variable type I collagen gels and their interaction with glioma cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
9514 633 2010 11 PDF Available
Title
Pore size variable type I collagen gels and their interaction with glioma cells
Abstract

Gelation temperatures from 22 °C to 37 °C were used to control the pore size of collagen matrices independent of collagen concentration. To limit cell exposure to temperatures lower than physiological temperature, the putative nucleation and growth mechanism of collagen was investigated to determine the time at which gel fibril and network structure becomes independent of temperature. It was found that the temperature dependent portion of collagen gelation ends close to the time at which fibrils first form a network spanning structure. These findings were then exploited to prepare cell-embedded gels nucleated at 22, 27, or 32 °C and then incubated at 37 °C. This achieves fibrillar and network structure characteristic of gels formed solely at the nucleation temperature. Proof of principle studies of glioma invasion in these gels suggested pore size is a key determinant of glioma invasive speed in collagen gels.

Keywords
Collagen; Hydrogel; Self-assembly; Elasticity; Cell morphology
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 31, Issue 21, July 2010, Pages 5678–5688
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us