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The fabrication of elastin-based hydrogels using high pressure CO2

Paper ID Volume ID Publish Year Pages File Format Full-Text
9518 634 2009 7 PDF Available
Title
The fabrication of elastin-based hydrogels using high pressure CO2
Abstract

The aim of this study was to investigate the effect of high pressure CO2 on the crosslinking of elastin-based polymers and the characteristics of the fabricated hydrogels. A hydrogel was fabricated by chemically crosslinking α-elastin with glutaraldehyde at high pressure CO2. The effects of pressure, reaction time, and crosslinker concentration on the characteristics of the fabricated hydrogels were determined. The reaction time had negligible effect on either the swelling ratio or the pore size of the fabricated hydrogels. Increasing the processing pressure from 30 bar to 150 bar resulted in a 60% increase in the hydrogel swelling ratio. The crosslinked hydrogels displayed stimuli-responsive characteristics towards temperature and salt concentration. The dense gas process facilitated coacervation, expedited the crosslinking reaction, and dramatically affected the micro- and macrostructures of pores within the sample. The results of micro-CT scan and SEM images demonstrated that pore interconnectivity was substantially enhanced for α-elastin hydrogels fabricated using high pressure CO2. Dense gas CO2 reduced the wall thickness and size of the pores and importantly induced channels within the structure of the α-elastin hydrogels. In vitro cell culture studies demonstrated that the channels facilitated fibroblast penetration and proliferation within α-elastin structures.

Keywords
Elastin; Hydrogel; Crosslinking; Glutaraldehyde; High pressure CO2; Fibroblast cells
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The fabrication of elastin-based hydrogels using high pressure CO2
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 1, January 2009, Pages 1–7
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us