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The cytotoxicity of cadmium based, aqueous phase – Synthesized, quantum dots and its modulation by surface coating

Paper ID Volume ID Publish Year Pages File Format Full-Text
9520 634 2009 7 PDF Available
Title
The cytotoxicity of cadmium based, aqueous phase – Synthesized, quantum dots and its modulation by surface coating
Abstract

In this report, we evaluated the cytotoxicity of a series of quantum dots (QDs) directly synthesized in aqueous phase, i.e., thiols-stabilized CdTe, CdTe/CdS core–shell structured and CdTe/CdS/ZnS core–shell–shell structured QDs, with a variety of cell lines including K562 and HEK293T. We have demonstrated that the CdTe QDs are highly toxic for cells due to the release of cadmium ions. Epitaxial growth of a CdS layer reduces the cytotoxicity of QDs to a small extent. However, the presence of a ZnS outlayer greatly improves the biocompatibility of QDs, with no observed cytotoxicity even at very high concentration and long-time exposure in cells. Our systematic investigation clearly shows that the cytotoxicity of QDs can be modulated through elaborate surface coatings and that the CdTe/CdS/ZnS core–shell–shell structured QDs directly synthesized in aqueous phase are highly promising biological fluorescent probes for cellular imaging.

Keywords
Aqueous phase; Biocompatible materials; Cytotoxicity; Core–shell–shell quantum dots
First Page Preview
The cytotoxicity of cadmium based, aqueous phase – Synthesized, quantum dots and its modulation by surface coating
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 1, January 2009, Pages 19–25
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering