fulltext.study @t Gmail

Culture media for the differentiation of mesenchymal stromal cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
953 70 2011 15 PDF Available
Title
Culture media for the differentiation of mesenchymal stromal cells
Abstract

Mesenchymal stromal cells (MSCs) can be isolated from various tissues such as bone marrow aspirates, fat or umbilical cord blood. These cells have the ability to proliferate in vitro and differentiate into a series of mesoderm-type lineages, including osteoblasts, chondrocytes, adipocytes, myocytes and vascular cells. Due to this ability, MSCs provide an appealing source of progenitor cells which may be used in the field of tissue regeneration for both research and clinical purposes. The key factors for successful MSC proliferation and differentiation in vitro are the culture conditions. Hence, we here summarize the culture media and their compositions currently available for the differentiation of MSCs towards osteogenic, chondrogenic, adipogenic, endothelial and vascular smooth muscle phenotypes. However, optimal combination of growth factors, cytokines and serum supplements and their concentration within the media is essential for the in vitro culture and differentiation of MSCs and thereby for their application in advanced tissue engineering.

Keywords
1,25-D3, 1,α25-dihydroxyvitamin D3; a2Col6, α chain 2 of type 6 collagen; ALP, alkaline phosphatase; asc, ascorbic acid; Asc-2-P, ascorbic acid 2-phosphate; AT, adipose tissue; BM, bone marrow; BM-MSCs, bone marrow-derived mesenchymal stromal cells; BMP,
First Page Preview
Culture media for the differentiation of mesenchymal stromal cells
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 2, February 2011, Pages 463–477
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us