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Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior

Paper ID Volume ID Publish Year Pages File Format Full-Text
9530 634 2009 8 PDF Available
Title
Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior
Abstract

A series of amphiphilic tri-block copolymers based on poly(lactide-co-glycolide)-b-poly(ethylene oxide)-b-poly(lactide-co-glycolide) (PLGE) with various segment ratios of PEO/PLGA and segment lengths of PEO were synthesized. Multi-morphological biodegradable nanoparticles – PLGE-NPs were fabricated by an improved emulsion/solvent evaporation technique in the absence of surfactant. By adjusting segment ratio of PLGA/PEO (w/w) and molecular weight of PEO, various morphological and nanoscale sized spheres, elliptic spheres, short rods and threads could be formed. The auto-assembling mechanism of the PLGE-NPs and influencing effectors of composition of the PLGE on morphology of the PLGE-NPs were discussed. The PLGE-NPs were biodegradable, and the factors that affected the degradation rate of the PLGE-NPs were also discussed. By using the amphiphilic PLGE polymer, the biodegradable nanoscale immunosuppressive agent – multi-morphological Cyclosporine (CsA)-loaded PLGE-NPs was fabricated. CsA release behavior of the CsA-loaded PLGE-NPs in vitro was determined, and the effect factors on CsA release behavior of the CsA-loaded PLGE-NPs were discussed.

Keywords
Poly(lactide-co-glycolide)-b-PEO-b-poly(lactide-co-glycolide) tri-block copolymer (PLGE); Nanoparticles (NPs); Multi-morphology; CsA drug delivery
First Page Preview
Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 30, Issue 1, January 2009, Pages 100–107
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering