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Ultra low fouling zwitterionic polymers with a biomimetic adhesive group

Paper ID Volume ID Publish Year Pages File Format Full-Text
9554 636 2008 6 PDF Available
Title
Ultra low fouling zwitterionic polymers with a biomimetic adhesive group
Abstract

Biomimetic polymers with a zwitterionic moiety for ultra low fouling and a catechol end group for surface anchoring have been developed. Binding tests of the adhesive polymers on various surfaces, including amino (NH2), hydroxyl (OH), and methyl (CH3) terminated self-assembled monolayers (SAMs) along with bare gold, were performed under acidic and basic conditions. Protein adsorption from single protein solutions of fibrinogen, lysozyme, and complex media of 10–100% blood plasma and serum was measured using a surface plasmon resonance (SPR) sensor. Under optimized conditions, the coated surfaces are highly resistant to non-specific protein adsorption from both single protein solutions and blood serum/plasma. Furthermore, the 3-day accumulation of Pseudomonas aeruginosa on the coated surfaces was evaluated in situ in a laminar flow chamber. Results show that the coated surfaces are highly resistant to bacterial adhesion and biofilm formation. This work demonstrates a convenient and efficient method for using zwitterionic polymers with a catechol anchor group to achieve ultra low fouling surfaces via surface modification, for applications in complex media.

Keywords
Zwitterionic; Catechol; Protein adsorption; Bacterial adhesion; Biofilm; Nonfouling
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Ultra low fouling zwitterionic polymers with a biomimetic adhesive group
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 35, December 2008, Pages 4592–4597
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us