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Strontium modified biocements with zero order release kinetics

Paper ID Volume ID Publish Year Pages File Format Full-Text
9565 636 2008 7 PDF Available
Title
Strontium modified biocements with zero order release kinetics
Abstract

Strontium-substituted β-TCP with the general formula Ca(3−x)Srx(PO4)2 (0 < x < 1) was synthesized by calcination of powder mixtures with the appropriate stoichiometry and reacted with acidic monocalcium phosphate monohydrate (MCPM) to form a cementitious matrix of secondary calcium phosphates. The use of Sr-substituted β-TCP as a reactant not only induced strontium substitution in the setting products but surprisingly it also favoured the formation of monetite (CaHPO4) as setting product, whereas Sr-free cements set to brushite (CaHPO4·2H2O). Release experiments under dynamic conditions for up to 15 days revealed the release of Sr2+ ions at dose ranges of 12–30 ppm with zero order release kinetic. Cement cytocompatibility was investigated by culturing human osteoblast cell line hFOB1.19 on cement surfaces whereas Sr-containing cements were as good as Sr-free cements in providing a template for cell growth and function.

Keywords
Brushite; Monetite; Calcium phosphate bone cement; Strontium substitution; Osteoblast; Biocompatibility
First Page Preview
Strontium modified biocements with zero order release kinetics
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 35, December 2008, Pages 4691–4697
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering