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The role of electrosprayed apatite nanocrystals in guiding osteoblast behaviour

Paper ID Volume ID Publish Year Pages File Format Full-Text
9579 637 2008 11 PDF Available
Title
The role of electrosprayed apatite nanocrystals in guiding osteoblast behaviour
Abstract

Apatite nanocrystals, which mimic the dimensions of natural bone mineral, were electrosprayed on glass substrates, as a suitable synthetic biomedical material for osteoblast outgrowth was explored. A variety of topographic patterns were deposited and the influence of these designs on osteoblast alignment and cell differentiation was investigated. Patterned cell growth and enhanced cell differentiation were seen. Osteoblasts were also cultured on apatite nanocrystals chemically modified with either carbonate or silicon ions. Enhanced cell proliferation and early formation of mineral nodules were observed on apatite nanocrystals with silicon addition. This work highlights the importance of the combined effects of surface topography and surface chemistry in the guidance of cell behaviour.

Keywords
Apatite; Carbonate; Electrospraying; Nanocrystals; Osteoblasts; Silicon
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The role of electrosprayed apatite nanocrystals in guiding osteoblast behaviour
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 29, Issue 12, April 2008, Pages 1833–1843
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us